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師資隊伍

喬豔甯博士

作者: 时间:2011年12月29日 01:42 点击数:

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喬豔甯,女,2013年畢業于南京大學模式動物研究所,在博士研究生期間主要從事平滑肌生理學研究。通過基因改造的動物模型或者動物疾病模型,研究平滑肌收縮的調節機制,以及平滑肌收縮與疾病發生的關系。曾通過條件性基因敲除小鼠模型研究發現MYPT1基因缺失會導致血管平滑肌收縮異常,從而導致高血壓的發生,建立了一個穩定的原發性高血壓模型。之前參與的研究發現肌球蛋白輕鏈激酶(MLCK)是血管平滑肌收縮和基礎血壓維持所必需的,也是高血壓發生的關鍵因素,以及肌球蛋白磷酸酶調節亞基(MYPT1)是腸道平滑肌表型轉換的關鍵因素。

受教育經曆:

2007/09-2013/06,南京大學,模式動物研究所,攻讀生物學博士學位,導師:朱敏生教授;

2003/09-2007/06,西北大學,生命科學學院,生命科學與技術基地班。

研究工作經曆:

2013/09-至今,陝西師範大學,現代教學技術教育部重點實驗室。

1.期刊論文

1)Qiao Y-N, He W-Q, Chen C-P, Zhang C-H, Zhao W, Wang P, Zhang L, Wu Y-Z, Yang X, Peng Y-J, Gao J-M, Kamm KE, Stull JT, and Zhu M-S*. Myosin Phosphatase Target Subunit 1 (MYPT1) Regulates the Contraction and Relaxation of Vascular Smooth Muscle and Maintains Blood Pressure. Journal of Biological Chemistry. 289, 22512-22523.2014. Impact factor: 4.8.

2)He W-Q, Qiao Y-N(co-first), Peng Y-J, Zha J-M, Zhang C-H, Chen C, Chen C-P, Wang P, Yang X, Li C-J, KammKE., Stull JT, Zhu MS*. Alteration of contractile phenotypes of intestinal smooth muscle from mice deficient in myosin phosphatase target subunit 1. Gastroenterology. 144: 1456-1465.2013.Impact factor: 12.

3)He W-Q, Qiao Y-N (co-first), Zhang C-H, Peng Y-J, Chen C, Wang P, Gao Y-Q, Chen C, Chen X, Tao T, Su X-H, Li C-J, Kamm KE, Stull JT, and Zhu M-S*. Role of myosin light chain kinase in regulation of basal blood pressure and maintenance of salt-induced hypertension. American Journal of Physiology - Heart and Circulatory Physiology 301: H584-H591, 2011. Impact factor: 3.7.

4)Peng Y-J, He W-Q, Tang J, Tao T, Chen C, Gao Y-Q, Zhang W-C, He X-Y, Dai Y-Y, Zhu N-C, Lv N, Zhang C-H, Qiao Y-N, Zhao L-P, Gao X, and Zhu M-S*. Trio Is a Key Guanine Nucleotide Exchange Factor Coordinating Regulation of the Migration and Morphogenesis of Granule Cells in the Developing Cerebellum. Journal of Biological Chemistry 285: 24834-24844, 2010. Impact factor: 4.8.

5)Zhang W-C, Peng Y-J, Zhang G-S, He W-Q, Qiao Y-N, Dong Y-Y, Gao Y-Q, Chen C, Zhang C-H, Li W, Shen H-H, Ning W, Kamm KE, Stull JT, Gao X, and Zhu M-S*. Myosin Light Chain Kinase Is Necessary for Tonic Airway Smooth Muscle Contraction. Journal of Biological Chemistry 285: 5522-5531, 2010. Impact factor: 4.8.

2.會議論文

1)In-vivo Role of MYPT1 in Orchestration of Vascular Smooth Muscle Contractility and Blood Pressure Maintenance. FASEB Summer Research Conference on Smooth Muscle, 2012, Colorado, American (Poster presentation).

2)Central role of RLC phosphorylation in vascular smooth muscle contractility and blood pressure maintenance. 13th Graduate Student Salon of Development and Cell Biology Conference, Jiangsu Province, 2012, Nantong, China (Oral presentation).

Loss of Myosin light chain kinase impairs maintenance of basal blood pressure and prevents salt-induced hypertension. 2nd Development and Cell Biology Conference, Jiangsu Province, 2009, Suzhou, China. (Excellent Poster presentation).